Aging, muscle stem cells, and self-renewal: a novel role for processing bodies in cytoplasmic mRNA coordination
Aging, muscle stem cells, and self-renewal: a novel role for processing bodies in cytoplasmic mRNA coordination Advancing age is associated with a decline in both the regenerative and self-renewing capacities of skeletal muscle stem cells, contributing to poor health and physical function in [...]
Engineering 3D muscle constructs to model age-related declines in muscle function and regeneration
Engineering 3D muscle constructs to model age-related declines in muscle function and regeneration Engineering biomimetic skeletal muscle systems that can model age-related muscle functional declines provides promising opportunities for understanding muscle aging and drug testing. In this project, we are developing three-dimensional muscle [...]
Knee osteoarthritis –where are the women?
Knee osteoarthritis –where are the women? As of 2020, an estimated 654.1 million adults live with knee osteoarthritis (KOA) worldwide. Notably, women who are post-menopausal have higher incidence and severity of KOA compared to men. Despite this disproportionate effect on women, most KOA [...]
Restoration of aging muscle stem cell self-renewal – the role of matrix stiffness on directing cell fate
Restoration of aging muscle stem cell self-renewal – the role of matrix stiffness on directing cell fate Resident muscle stem cells (MuSCs) are essential for the regeneration of muscle. However, over time, there is a gradual depletion of the MuSC pool. While aged [...]
Quantum Biology
Quantum Biology: a novel approach to tackling some of biology’s most complex puzzles In 1944, Erwin Schrödinger asked the question, “What is life?” In his book of the same title, Schrödinger posited that the very quantum principles that direct the behaviors of objects [...]
Enhancing skeletal muscle regeneration through magnetic field exposure
Enhancing skeletal muscle regeneration through magnetic field exposure Over the last century, medicine has evolved towards greater precision with minimal invasion. This trend has led to the development of revolutionary technologies, including magnetic resonance imaging (MRI). Although magnetic field modulation to develop images [...]
Photomedicine and its implications in muscle regeneration
Photomedicine and its implications in muscle regeneration Low-level laser therapy has been used to optimize wound healing for decades. More recently, clinical studies have shown that biophotomodulation enhances the efficacy of rehabilitation approaches designed to enhance skeletal muscle regeneration. However, the molecular mechanisms [...]
Priming extracellular vesicles to promote aged skeletal muscle regeneration
Priming extracellular vesicles to promote aged skeletal muscle regeneration Kai Wang, PH.D. The regenerative capability of skeletal muscle tissue is largely impaired by aging. Therefore, developing effective strategies to promote aged skeletal muscle regeneration becomes an important public health priority. Muscle stem cell-based [...]
Development of α-Klotho therapeutics
Development of α-Klotho therapeutics Hirotaka Ijima, PH.D. British anatomist William Hunter (1718-1783) stated “…articular cartilage, when it is injured or possesses pathology, does not heal”. Although we have known of the poor healing capacity of cartilage for over 200 years, this limited capacity [...]
Effects of age and sex on extracellular vesicle mediated skeletal muscle regeneration
Effects of age and sex on extracellular vesicle mediated skeletal muscle regeneration Aging leads to progressive loss of skeletal muscle mass and strength and is associated with increasing morbidity and disability. Preliminary studies by Drs. Sahu and Ambrosio and have found that extracellular [...]
The fidelity of the genetic information transfer with aging
The fidelity of the genetic information transfer with aging Sruthi Sivakumar Aging is the biggest risk factor for most chronic and degenerative diseases. Due to differences in nature versus nurture, physiological aging in people happens at widely different rates. If we can understand [...]
Exploring the role of environmental exposure
Exploring the role of environmental exposure Zach Clemens Certainly, each person’s genome exerts tremendous effect on the development and maintenance of the musculature throughout their lifetime. However, this is not to say that this is set in stone at birth. Throughout our lifetimes [...]